Flames broke out in a restaurant on the first floor of the building on Grand Concourse just after 2 a.m.
Video showed the flames reaching the roof of the four story building.
Firefighters brought the fire under control just after 5 a.m.
One firefighters was hurt, but they extent of their injuries is not yet clear.
The Red Cross said it provided assistance to three families that displaced by the fire, including seven adults and three children.
The cause of the fire is under investigation.
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